Patient and physician scores were assessed at 1 month and 3 months after the last treatment. They were treated with six sessions at two weekly intervals using a 1,064-nm QSNY laser. Seventy-eight patients with postacne hyperpigmentation were included in the study. The aim was to review our experience with 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QSNY) laser in the treatment of PIH. Very few therapeutic modalities have proved to be really efficacious in this condition. It is psychologically extremely disturbing for the patients and can severely affect the quality of life. Postinflammatory hyperpigmentation (PIH) is a common sequela seen in the Indian population following affliction by acne. We also believe that dermoscopy could be helpful tool for assessment of pigmentation depth in patients on treatment by analyzing the color pattern. Both fractional CO2 laser and TXA microinjection are effective and safe treatment options for post-acne hyperpigmentation with potential superiority of fractional CO2 laser. There was statistically significant difference with better percentage of improvement regarding total dermoscopic score on the fractional CO2 laser side than the TXA microinjections side (P < 0.009). Both fractional CO2 laser and TXA microinjection treatment sides showed a significant reduction in the PAHPI and MI (P < 0.001). Efficacy was evaluated using digital photography, dermoscopy, post-acne hyperpigmentation index (PAHPI), melanin index (MI), and erythema index (EI) at baseline and four weeks after the last session. One side of the face was randomly assigned to low-power fractional CO2 laser every four weeks and the other side was assigned to TXA intradermal-microinjection every two weeks for three months. Twenty-five post-acne hyperpigmentation patients (resistant to regular treatment for more than six months) were enrolled in this randomized split-face study. This study's objective was to compare the efficacy of both low-power/low-density fractional carbon-dioxide (CO2) laser and tranexamic acid (TXA) microinjection on post-acne hyperpigmentation. Post-acne hyperpigmentation is a common undesirable sequela of acne vulgaris that causes distress for many patients. É possível observar a forma irregular e o aumento do tamanho das papilas dérmicas, perda na definição do contorno, epiderme mais pigmentada (espaço entre as papilas), pois há maior quantidade de melanina e concentração irregular de melanina quando comparada à região perilesional (Escala 500 x500 µm). É possível observar papilas dérmicas regulares (redondas) com bordas bem definidas e esbranquiçadas e um espaço totalmente escuro entre elas, representando uma pigmentação regular (Escala 500 x500 µm) (B) Junção dermoepidérmica da região lesional.
![texto contraste del acne texto contraste del acne](http://2.bp.blogspot.com/-5XvbZhEgtDI/VlN0IQCKk2I/AAAAAAAALQ8/nWhVciBiYfI/s1600/Espanol.6to.grado.2015-2016.LibrosSEP_132.jpg)
It is possible to observe the irregular shape and increased size of dermal papillas, loss in their contour definition, more pigmented epidermis (space between the papillas) due to the higher amount and irregular concentration of melamin when compared to perilesional region (Scale 500 x500 µm)/ (A) Junção dermoepidérmica da região perilesional. It is possible to observe regular shapped (round) dermal-pappilas with well-defined and whitish borders and an totally dark space between them representing an regular pigmentation (Scale 500 x500 µm) (B) Dermal-epidermal junction of lesional region. Figura 3 -(A) Dermal-epidermal junction of perilesional region. Finally, the study describes the characteristics of PIH and can help dermatologists toĭiagnose PIH with an innovative method that reduces the stress associated with a histological biopsy. Melanophages were observed in the papillary dermis, as well as changes in the size and shape of dermal papillae. The results showed an increase of epidermal pigmentation, a reduction of DEJ thickness, and no change in epidermal thickness. The brightness of the basal cell layer, the dermal-epidermal junction (DEJ) thickness, and the depth of dermal papillae were quantified and the morphological and structural features of the DEJ were analyzed. Thus, 12 subjects with previously diagnosed acne and PIH were selected for the study. The aim of this study was to characterize PIH and correlate the main aspects observed by RCM with the macroscopic characteristics of acne-related PIH. However, Reflectance Confocal Microscopy (RCM) has the potential to replace these methods since it is a noninvasive advanced technique and has a higher diagnostic accuracy than dermatoscopy.
![texto contraste del acne texto contraste del acne](https://maldita.es/app/uploads/2020/06/apple-1771906_1920-1024x683.jpg)
Histological and clinical exams have been used for the diagnosis of PIH and to determine the correct treatment. Post-Inflammatory Hyperpigmentation (PIH) is a common pigmentary disorder in patients with pigmented skin.